Publications – Helen He Zhu's lab

Liu, K., Jing, N., Wang, D., Xu, P., Wang, J., Chen, X., Cheng, C., Xin, Z., He, Y., Zhao, H., Ji, Z., Zhang, P., Gao, W., Zhu, H.H.*, Zhang, K*., 2021. A novel mouse model for liver metastasis of prostate cancer reveals dynamic tumour‐immune cell communication. Cell Prolif 54.
Wang, X., Xu, H., Cheng, C., Ji Z., Zhao, H., Sheng, Y., Li, X., Wang, J., Shu, Y., He Yu., Fan, L., Dong, B., Xue, W., Chua, C.W., Wu, D., Gao, W.Q. *, Zhu, H.H.* (2020) Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate. Nature Communications. 11（1）：706
Ji Z, Sheng Y, Miao J, Li X, Zhao H, Wang J, Cheng C, Wang X, Liu K, Zhang K, Xu L, Yao J, Shen L, Hou J, Zhou W, Sun J, Li L, Gao W-Q *, Zhu ,H.H.* (2019) The histone methyltransferase Setd2 is indispensable for V(D)J recombination. Nature Communications. 10, 3353.
Sheng Y, Ji Z, Zhao H, Wang J, Cheng C, Xu W, Wang X, He Y, Liu K, Li L, Voeltzel T, Maguer‐Satta V, Gao W-Q.* ,Zhu,H.H.* (2019) Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells. Cell Prolif.
Wang, X.#, Dong, B.#, Zhang, K., Ji, Z., Cheng, C., Zhao, H., Sheng, Y., Li, X., Fan, L., Xue, W., Gao, W-Q.*, Zhu, H.H.* （2018）E-cadherin bridges cell polarity and spindle orientation to ensure prostate epithelial integrity and prevent carcinogenesis in vivo. Plos Genetics. 14(8): e1007609
Cheng, C. #, Ji, Z. #, Sheng, Y., Wang, J., Sun, Y., Zhao, H., Li, X., Wang, X., He, Y., Yao, J., Wang, L., Zhang, C., Guo, Y., Gao, W.Q.*, Zhu, H.H.* An Aphthous Ulcer Drug Inhibits Prostate Tumor Metastasis By Targeting The IKKɛ/TBK1/NF-κB Theranostics. 8, 4633-4648
Guo,Y., Zhang, K., Cheng, C., Ji, Z. , Wang, X., Wang, M., Chu, M., Tang, D.G., Zhu, H.H.* and Gao, W.Q.* (2017) Numb-/low enriches a castration resistant prostate cancer cell subpopulation associated with enhanced Notch and Hedgehog signaling. Clinical Cancer Research. 23:6744-6756
Zhang, K., Guo, Y., Wang, X., Zhao, H., Ji, Z., Cheng, C., Li, L., Fang, Y., Xu, D., Zhu, H.H.*, and Gao, W.Q.* (2017) WNT/β-catenin Directs Self-Renewal Symmetric Cell Division of hTERT^high Prostate Cancer Stem Cells. Cancer Research. 77(9):2534-2547.
Guo,Y.#, Cui,J.#, Ji, Z., Cheng, C., Zhang, K., Zhang, C., Chu,M., Zhao, Q., Yu, Z., Zhang, Y., Fang,Y.X., Gao, W.Q.*, and Zhu, H.H.*(2017)MiR-302/367/LATS2/YAP Pathway is Essential for Prostate Tumor-Propagating Cells and Promotes the Development of Castration Resistance. Oncogene 36:6336-6347
Zhang, C., Ji, Z., Wang, M., Zhang, W., Yang, R., An, H., Yang, R., Abel, D.V., Dijk, M.V., Yang, X., Ou, G., Zhu, H. H.*, and Gao, W. Q.* (2016) Stox1 as a Novel Transcriptional Suppressor of Math1 during Cerebellar Granule Neurogenesis and Medulloblastoma Formation. Cell Death and Differentiaion. 23, 2042–2053
Zhang, K., Zhao, H., Ji, Z., Zhang, C., Zhou, P., Wang, L., Chen, Q., Wang, J., Zhang, P., Chen, Z., Zhu, H. H.*, and Gao, W. Q.* (2016). Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition. Oncogene. 10;35(10):1271-82
Zhu, H. H.#, Zhuang, G.#, and Gao, W. Q. (2016). A candidate gastric stem/progenitor cell marker revealed by genome-wide analysis. The Journal of pathology. 238(1):3-6.
Zhu, H.H.*, Luo, X., Zhang, K., Cui, J., Zhao, H., Ji, Z., Zhou, Z., Yao, J., Zeng, L., Ji, K., Gao, W.Q., Zhang, Z.Y., Feng, G.S.* (2015) Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proceedings of the National Academy of Sciences of the United States of America 112: 13342-13347
Wang, L., Zhang, K., Zhu, H. H.*, and Gao, W. Q.* (2015). Autonomous assembly of epithelial structures by subrenal implantation of dissociated embryonic inner-ear cells. Neuroreport 26, 473-477.
Zhou, Z., Ji, Z., Wang, Y., Li, J., Cao, H., Zhu, H. H.*, and Gao, W. Q.* (2014). TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. Gastroenterology 147, 1043-1054.
Zhang, C., Guo, Y., Cui, J., Zhu, H. H.*, and Gao, W. Q.* (2013). Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration. BioMed research international 2013, 576472.
Zhu, H. H., Ji, K., Alderson, N., He, Z., Li, S., Liu, W., Zhang, D. E., Li, L., and Feng, G. S. (2011). Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool. Blood 117, 5350-5361.
Zhu, H. H., and Feng, G. S. (2011). The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell cycle 10, 2241-2242.

其他共同作者论文

Zhai, Y.#, Wang, J.#, Lang, T., Kong, Y., Rong, R., Cai, Y., Ran, W., Xiong, F., Zheng, C., Wang, Y., Yu, Y., Zhu, H.H., Zhang, P.*, Li, Y.*, 2021. T lymphocyte membrane-decorated epigenetic nanoinducer of interferons for cancer immunotherapy. Nature Nanotechnology.
Luo, X., Liao, R., Hanley, K.L., Zhu, H.H., Malo, K.N., Hernandez, C., Wei, X., Varki, N. M., Alderson, N., Chu, C., Li, S., Fan, J., Loomba, R., Qiu, S. J., and Feng, G.S. (2016) Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell reports 2016;17(11):2979-93
Chen, W.S., Zhu, H.H., Feng, G.S.. Treating leukemia at the risk of inducing severe anemia. Experimental hematology. 2016;44(5):329-31.
Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H (2015) Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nature immunology 16: 642-652
Shu, Q., Cai, T., Chen, X., Zhu, H. H., Xue, P., Zhu, N., Xie, Z., Wei, S., Zhang, Q., Niu, L., Gao, W. Q., and Yang, F. (2015). Proteomic Comparison and MRM-Based Comparative Analysis of Metabolites Reveal Metabolic Shift in Human Prostate Cancer Cell Lines. Journal of proteome research 14, 3390-3402.
Nie, X., Zhang, K., Wang, L., Ou, G., Zhu, H., and Gao, W. Q. (2015). Transcription factor STOX1 regulates proliferation of inner ear epithelial cells via the AKT pathway. Cell proliferation 48, 209-220.
Clement, F., Zhu, H.H., Gao, W.Q., Delay, E., Maguer-Satta, V. (2015) Quantifying Epithelial Early Common Progenitors from Long-Term Primary or Cell Line Sphere Culture. Current protocols in stem cell biology 35: 1E 7 1-8
Wang, J., Zhu, H. H., Chu, M., Liu, Y., Zhang, C., Liu, G., Yang, X., Yang, R., and Gao, W. Q. (2014). Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages. Nature communications 5, 4758.
Li, S., Hsu, D. D., Li, B., Luo, X., Alderson, N., Qiao, L., Ma, L., Zhu, H. H., He, Z., Suino-Powell, K., Ji, K., Li, J., Shao, J., Xu, H. E., Li, T., and Feng, G. S. (2014). Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell metabolism 20, 320-332.
Li, X., Liu, Y., Chen, W., Fang, Y., Xu, H., Zhu, H. H., Chu, M., Li, W., Zhuang, G., and Gao, W. Q. (2014). TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer. Oncotarget 5, 9498-9513.
He, Z., Zhu, H. H., Bauler, T. J., Wang, J., Ciaraldi, T., Alderson, N., Li, S., Raquil, M. A., Ji, K., Wang, S., et al. (2013). Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proceedings of the National Academy of Sciences of the United States of America 110, E79-88.
Yu, J., Deng, R., Zhu, H. H., Zhang, S. S., Zhu, C., Montminy, M., Davis, R., and Feng, G. S. (2013). Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. The Journal of biological chemistry 288, 3823-3830.
He, Z., Zhang, S. S., Meng, Q., Li, S., Zhu, H. H., Raquil, M. A., Alderson, N., Zhang, H., Wu, J., Rui, L., et al. (2012). Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Molecular and cellular biology 32, 1867-1878.
Huang, H., Woo, A. J., Waldon, Z., Schindler, Y., Moran, T. B., Zhu, H. H., Feng, G. S., Steen, H., and Cantor, A. B. (2012). A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes & development 26, 1587-1601.
Bard-Chapeau, E. A., Li, S., Ding, J., Zhang, S. S., Zhu, H. H., Princen, F., Fang, D. D., Han, T., Bailly-Maitre, B., Poli, V., Varki, N. M., Wang, H., and Feng, G. S. (2011). Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer cell 19, 629-639.
McPherson, V. A., Sharma, N., Everingham, S., Smith, J., Zhu, H. H., Feng, G. S., and Craig, A. W. (2009). SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells. Journal of immunology 183, 4940-4947.